The preparation and properties of ergothioneine disulphide.
نویسندگان
چکیده
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منابع مشابه
A convenient spectrophotometric assay for the determination of L-ergothioneine in blood.
1. A convenient spectrophotometric assay for the determination of l-ergothioneine in solution including deproteinized blood haemolysate was developed. 2. The method consists of deproteinization by heat precipitation and Cu(2+)-catalysed oxidation of thiols such as glutathione and of l-ascorbic acid, both in alkaline media, and titration of l-ergothioneine (which is not oxidized under these cond...
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Ergothioneine and mycothiol are low molecular mass redox protective thiols present in actinomycetes, in particular mycobacteria. We report the improved chemical synthesis of ergothioneine (ESH) and biosynthetic pathway intermediates using either histidine or ESH as the starting material. The detailed mechanism of ESH biosynthesis has not yet been completely elucidated and substrates for enzymes...
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Ergothioneine was synthesized and accumulated in growing cultures of Mycobacterium smegmatis when the medium was adequately supplied with sulfur. In a low sulfur medium, the accumulation was sharply limited although growth of the organism was apparently normal. Synthesis of hercynine, the precursor of ergothioneine, was unaffected by low sulfur levels and was markedly increased by addition of l...
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Redox reactions of endogenous and exogenous sulphur-containing compounds are involved in protection against oxidative damage arising from the incidence and/or treatment of many diseases, including cancer. We have investigated, via pulse radiolysis, the one-electron oxidation of ergothioneine, a molecule with antioxidant properties which is detected at millimolar concentrations in certain tissue...
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Studies in this Laboratory with isotope-labeled compounds have given no evidence for the synthesis of ergothioneine by the rat, chicken, guinea pig, or human (1). On the other hand Heath and coworkers (2) have concluded from similar experiments that the boar does synthesize ergothioneine. We now report the results of studies on a young pig, in which we find no evidence for ergothioneine synthes...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 68 2 شماره
صفحات -
تاریخ انتشار 1958